Dimethocaine was originally synthesized by the Hoffmann-La Roche company in 1930. It was sold under the market name larocaine. During the 1930s dimethocaine gained popularity in the US as a local anesthetic. Just like cocaine and procaine, it was used during surgery, primarily in dentistry, ophthalmology … See more Dimethocaine, also known as DMC or larocaine, is a compound with a stimulatory effect. This effect resembles that of cocaine, although dimethocaine appears to be less potent. Just like cocaine, … See more Pharmacodynamics Dimethocaine and structurally related local anesthetics such as cocaine and procaine inhibit the uptake of dopamine (DA) by blocking dopamine transporters (DAT). The dopamine transporter controls the dynamics of the See more Humans Cocaine and other local anesthetics are known to produce cardiotoxicity by blocking sodium channels. However, no reports have been … See more • 3-(p-Fluorobenzoyloxy)tropane • Nitracaine • List of cocaine analogues See more The exact metabolic pathways of dimethocaine have not been researched, but the different metabolites have been examined in Wistar rats. After administration of … See more Just like cocaine, dimethocaine inhibits the uptake of dopamine in the brain by interfering with the dopamine transporters. The potency of … See more Sweden's public health agency suggested classifying Dimethocaine as a hazardous substance, on September 25, 2024. See more WebFeb 1, 2024 · “Synthacaines”: A mosaic of substances for a wide range of effects, from a case Authors: Guillaume Deslandes Centre Hospitalier Universitaire de Nantes Catherine …

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