Slco1b1 and simvastatin
WebJan 3, 2024 · Therapeutic recommendations for statins based on SLCO1B1, ABCG2, and CYP2C9 genotype are provided with the goal of improving the overall safety, adherence, and effectiveness of statin therapy. Expand. 43. Save. Alert. Statin exposure is associated with reduced development of acute on chronic liver failure in a veterans affairs cohort. WebNational Center for Biotechnology Information
Slco1b1 and simvastatin
Did you know?
WebAug 17, 2015 · Individual and combined associations of genetic variants in CYP3A4, CYP3A5, and SLCO1B1 with simvastatin and simvastatin acid … WebAug 15, 2024 · Conclusion: The genetic variants of SLCO1B1 and ABCB1 predict the lipid-lowering efficacy of atorvastatin, and this may be useful in genotype-guided statin therapy for coronary artery disease patients. Keywords: atorvastatin ATP binding cassette transporters cytochrome P450 drug efficacy pharmacogenomics solute carrier …
WebDec 13, 2024 · Many variants in SLCO1B1 have been identified, but the c.521T>C variant (rs4149056) is most clinically relevant. Relationship between rs4149056 and simvastatin-induced muscle toxicity clearly established. Genetic testing for SLCO1B1 may be considered to identify patients at increased risk of developing simvastatin-induced myopathy. … WebNov 3, 2009 · Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) are well established in the treatment of hypercholesterolaemia and the prevention of coronary …
WebMar 28, 2024 · The SLCO1B1 c.521T>C variant significantly increased exposure to simvastatin acid by around 40% (p < 0.05), similar to that caused by the amlodipine pretreatment. The ABCB1 gene showed no influence on exposure to simvastatin or simvastatin acid. Conclusion Only SLCO1B1, not ABCB1 genotype, is likely to be … WebJun 11, 2014 · We summarize evidence from the literature supporting this association and provide therapeutic recommendations for simvastatin based on SLCO1B1 genotype. This …
WebSLCO1B1 encodes a transporter (SLCO1B1; alternative names include OATP1B1 or OATP-C) that facilitates the hepatic uptake of all statins. ABCG2 encodes an efflux transporter (BCRP) that modulates the absorption and disposition of rosuvastatin. CYP2C9 encodes a phase I drug metabolizing enzyme responsible for the oxidation of some statins.
WebNov 8, 2024 · All statins are substrates for organic anion-transporting polypeptides 1B1 (OATP1B1), the transport activity of which is associated with the SLCO1B1 gene. At the same time, OATP1B1 is the only transporter of simvastatin. Rosuvastatin is a substrate for OATP1B3 and OATP2B1, and atorvastatin is a substrate for OATP2B1 [ 19 ]. china garden shanklin isle of wightWebSLCO1B1 proteins help carry certain medicines so your body can use them. These medicines include statins, which are used to lower cholesterol. Statins include the following medicines: Atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, and … grahame simmonsWebJan 15, 2024 · SLCO1B1*5 and SLCO1B1*15 have been extensively associated with myopathy to simvastatin. A systematic review and meta-analysis reported that carriers of the C allele of SLCO1B1*5 (c.521T>C) showed a higher risk of myotoxicity . Additionally, SLCO1B1*5 has been associated to rosuvastatin myotoxicity in previous studies (18,19). grahame robb associatesWebSLCO1B1 -Simvastatin—Beyond drug-metabolizing gene products (e.g., CYP2C19, CYP2D6, TPMT, etc.), drug transporters as products of PK pharmacogenes also affect drug … grahame smith facebookWebJun 11, 2014 · A single coding single-nucleotide polymorphism, rs4149056T>C, in SLCO1B1 increases systemic exposure to simvastatin and the risk of muscle toxicity. We summarize evidence from the literature supporting this association and provide therapeutic recommendations for simvastatin based on SLCO1B1 genotype. china garden restaurant winnipegWebConclusion: This is the first study to demonstrate that common genetic variability within the SLCO1B1 and ABCB1 genes is associated with the modification of the effectiveness of statins in the prevention of the clinical outcome, myocardial infarction. grahame shearmanWebJul 7, 2024 · SLCO1B1 genotype information is increasingly being utilized to guide the selection and dosing of several statins, especially simvastatin. 15 - 17 Genetic variation in another transporter, ABCG2, and the gene encoding the drug metabolizing enzyme CYP2C9 have also been shown to be relevant for statin prescribing in addition to SLCO1B1 … grahame smart obituary