Web7 apr. 2024 · Furthermore, we also 98 investigated the cell‒cell contact between CCs and TCs. CCs were predicted to 99 interact with TCs via SPP1-CD44, MIF (macrophage migration inhibitory factor)-100 (CD74/CD44/CXCR4), and CD70-CD27 (Fig. S2F). Web14 jul. 2009 · The MIF receptor CD74 is overexpressed in invasive MDA-MB-231 cells. (a) Comparison of CD74 expression levels between MDA-MB-231, non-invasive MDA-MB-468, and non-tumorous MCF-12A cells by Western blot analysis. Lysates of non-stimulated cells were analysed by Western blot and band densitometry analysis against human CD74 …
Frontiers The role of CD74 in cardiovascular disease
WebRab22a is an important small GTPase protein the molecule that is involved in intracellular transportation and regulation of proteins. It also plays an important role in antigens uptake, transportation, regulation of endosome morphology, and also regulates the transport of antigens to MHC (Major Histocompatibility Complex) molecules. To investigate the role … Web26 mrt. 2024 · The receptor CD74, and co-receptors such as CD44, CXC-chemokine receptor 2 (CXCR2) and CXCR4, mediate the effects of MIF in tumour cells, including … blackberry theme
MIF, CD74 and other partners in kidney disease: Tales of a …
WebMechanistically, MIF induces intracellular signal cascades via binding to its receptors including the cardioprotective CD74/AMPK kinase axis and the MIF CXC motif chemokine receptors, CXCR2, CXCR4, or CXCR7. Serum MIF may influence the expression of MIF receptors, and there are indications from mouse models that genetic MIF deficiency ... WebOverall, the receptors CD74, CXCR4, and CXCR2 have been shown to mediate the predominant effects of MIF in vitro and in vivo . We therefore determined the expression of each of these receptors on murine HSCs. As determined by FACS analysis, CD74 is the most abundant MIF receptor on HSCs, and CXCR4 was present at lower expression … Web4 mrt. 2024 · MIF is also a noncognate ligand of the CXCRs, CXCR2, and CXCR4, and biochemical evidence suggests that these chemokine receptors could act as additional … blackberry theme free download