Choline kinase
Choline kinase (also known as CK, ChoK and choline phosphokinase) is an enzyme which catalyzes the first reaction in the choline pathway for phosphatidylcholine (PC) biosynthesis. This reaction involves the transfer of a phosphate group from adenosine triphosphate (ATP) to choline in order to form phosphocholine. ATP … See more As of late 2007, six structures have been solved for this class of enzymes, with PDB accession codes 1NW1, 2CKO, 2CKP, 2CKQ, 2I7Q, and 2IG7. CKα-2 originating from C. elegans, is a dimeric enzyme … See more Choline kinase catalyzes the formation of phoshocholine, the committed step in phosphatidylcholine biosynthesis. Phosphatidylcholine is the major phospholipid in … See more Oncogenic activity and CKα-1 Overexpression of CKα-1 has been found to be associated with cancer. Recent studies carried out on cancer cell lines have shown that CKα-1 is over-expressed in breast cancer cells. This leads to an accumulation of … See more Although not much is known about the mechanism by which choline kinase reacts, the recent advancement in the elucidation of the … See more After closely studying the structurally similar enzymes, CKα-2, APH(3′)-IIIa, and PKA, researchers observed that PKA had less insertions to its structural core compared to the … See more Choline kinase α can act as a protein chaperone. Kinase can function as chaperone and there may be other kinases that may function as chaperone that are yet to be … See more • Hayashi SI, Lin EC (March 1967). "Purification and properties of glycerol kinase from Escherichia coli". The Journal of Biological Chemistry. 242 (5): 1030–5. PMID 5335908. • Wittenberg J, Kornberg A (May 1953). "Choline phosphokinase". The Journal of … See more WebDOI: 10.1016/j.bcp.2024.07.004 Abstract Choline kinase alpha 1 (ChoKα1) has recently become an interesting therapeutic target since its overexpression has been associated to tumorigenesis in many cancers. Nevertheless, little is …
Choline kinase
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WebOct 7, 2010 · TCD Pharma has developed TCD-717, a novel drug that is a specific inhibitor of the enzyme choline kinase alpha (ChoKα), involved in the synthesis of phosphatidylcholine, which constitutes the major phospholipid in eukaryotic cell membranes and has been described as a potent oncogen when overexpressed in human cells. WebNov 26, 2013 · Choline kinase-alpha expression was inhibited by specific transient RNA interference in two EOC cell lines, INTOV11 and SKOV3, with known ChoK-alpha …
WebSep 8, 2024 · The CHKA gene codes for the choline kinase alpha enzyme, which is involved in the CDP-choline pathway of reactions that convert choline into … WebCholine kinase for PC synthesis de novo—and phosphatidate phosphatase—is regulatory in other organs. 93 Although choline kinase is not rate limiting by itself, plasma choline …
WebOct 3, 2024 · Choline kinase α (CHKα) is the first rate-limiting enzyme in choline metabolism that catalyzes choline phosphorylation to yield phosphorylcholine (PC) in the phosphatidylcholine (PtdCho ... WebApr 4, 2024 · EB-3D is a potent and selective choline kinase alpha 1 (ChoKα1) inhibitor. It induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells. EB-3D displays excellent antiproliferative activity against a wide cohort of T-leukemic cell lines, with GI 50 values in the nanomolar range and resulting in more cytotoxic.
WebOct 15, 2024 · Choline Kinase in Eurkaryotic Cells. Choline kinase catalyzes the conversion of choline (Cho) to phosphocholine (PCho) via the transfer of a phosphate group from ATP to Cho ( Wittenberg and Kornberg, 1953 ). ChoK phosphorylation of Cho is the first step in the Kennedy pathway, which is responsible for the cell membrane component ...
WebEnter the email address you signed up with and we'll email you a reset link. in union with meaningWebIdentify choline kinase alpha as a key regulator of glutathione-dependent antioxidant cell defense in ovarian carcinoma. choline kinase alpha is inhibited by a near-infrared … in uniform circular motion both velocityWebCholine kinase (Chk) catalyzes choline phosphorylation to produce PC in phosphatidylcholine (PtdCho) biosynthesis. PtdCho is the most abundant phospholipid in eukaryotic cell membranes and plays a dual role as the structural component of membranes and as a substrate to produce lipid second messengers such as phosphatidic acid and … in unicellular organism mitosis is used forWebThe phosphorylation by choline-kinase is the first step in the Kennedy pathway which is responsible for the biosynthesis of choline phospholipids such as phosphatidylcholine (PtdCho) (18-20). PtdCho is required for the build–up and maintenance of cell membranes. It also serves as a precursor of diacylglycerol (DAG), that has an important in unit pricing a.p. stands forWebJul 1, 2024 · Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets Authors Rui Liu 1 , Jong-Ho Lee 2 , Jingyi Li 3 , Rilei Yu 4 , Lin Tan 5 , Yan Xia 6 , Yanhua Zheng 6 , Xue-Li Bian 7 , Philip L Lorenzi 5 , Qianming Chen 8 , … in unison wollongongWebOval cells in the liver were identified morphologically and by expression of pi-glutathione S-transferase (pi-GST), alpha-fetoprotein (AFP) and the embryonic isoform of pyruvate kinase (M2-PK). Oval cell numbers and changes in the pattern of gene expression induced by the CDE diet were accelerated by pre-treatment with ethanol. in unison - crosswordWebCholine kinase (ChoK) is the first enzyme of the Kennedy pathway leading to the biosynthesis of phosphatidylcholine (PtdCho), the most abundant phospholipid in … in uniform circular motion what changes