WebNov 15, 2013 · The B7-H3 (B7-homolog 3 or CD276) is a type I transmembrane protein and a member of the B7 family. B7-H3 is expressed in many tissues and in antigen-presenting cells. Its functions and counter receptor (s) remain unclear. The expression of the B7-H3 protein by the tumor microenvironment and tumor cells modifies the antitumor immune … WebヒトB7−H3 (2Ig型)は、活性化されたT細胞上の推定受容体に結合することによりT細胞の活性 化およびIFN−γの産生を促進することが分かっている(非特許文献16;非特許文献 20)。 B7−H4およびB7−H1は双方とも、腫瘍細胞上で発現した場合には免疫機 能の強力な阻害剤となる(非特許文献12)。...
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Anti-B7-H3 Antibody (C-1) SCBT - Santa Cruz Biotechnology
WebMar 2, 2024 · Abstract. B7-H3 (CD276), a member of the B7 family of proteins, is a key player in cancer progression. This immune checkpoint molecule is selectively expressed in both tumor cells and immune cells within the tumor microenvironment. In addition to its immune checkpoint function, B7-H3 has been linked to tumor cell proliferation, … WebJun 14, 2024 · The B7 family member B7-H3 is upregulated in a variety of human cancers and constitutes, together with PD-L1, an important immune checkpoint protein involved in the inhibition of T-cell activation. 27-29 In addition to its effect on anticancer immunity, B7-H3 favors tumor cell proliferation, migration, and invasion as well as the glycolytic and ... WebB7-H3はB7-familyに属する免疫関連分子で,腫瘍細胞で特異的に高発現している。 筆者らの検討により,B7-H3は非小細胞肺がんのおよそ75%で発現を認め,さらにB7-H3陽 … does a thick uterine lining mean cancer